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Editor’s note: The following column was submitted by a Pepperell woman who has suffered with depression throughout her life. She said the doctor captures very well the agonies of the disease while offering hope to those who suffer. She asked that we share it.

Robin Williams, a comic genius and one of the great storytellers of our time, apparently chose to end his life because he could not see the next chapter of his own story as containing anything other than unbearable psychological pain.

Such is the power of depression — an affliction almost unimaginable to those who have not suffered with it — to twist the truth into something unrecognizable. For the truth is that there were many new and wonderful pages awaiting Robin Williams; he just couldn’t imagine them. He couldn’t believe the darkness would ever end.

Depression is the grand imposter — posing as all powerful. It can be defeated, every time, if you or the person you care about confronts it like the grand imposter that it is.

Depression is always, to an extent, a psychotic illness. It steals reality — which is, in large measure, defined by the completely justifiable hope in tomorrow’s possibilities — and replaces it with a world in which one doubts his or her abilities, discounts to zero his or her past successes, doubts love, doubts friendship and doubts God.

In its worst forms, it is much more than profound sadness; it is the conviction that nothing good will ever occur, sometimes coupled with horrific and constant anxiety that something unspeakably terrible is about to happen — in a minute, or this very night, or tomorrow.

If life is, for all of us, a labyrinth, with sometimes frustrating twists and turns on the way to the center, depression makes life seem, instead, like a never-ending and inescapable maze, with dead ends, frustrations and traps in every direction.

This scourge affected 17-20 million adults in the last year alone. Suicide is epidemic now. And our mental health care system is in ruins, so unable to respond that cities are spending tens of millions to build nets under their bridges to catch (those who see only the blackness of hopelessness).

I have treated a billionaire who was convinced, with no basis, whatsoever, that his investments were all crumbling.

I have treated a college student who could not leave her room, then not even the bed, so paralyzing was her low energy, coupled with fear.

I have now treated a few thousand people with depression. I have lost not a single one to suicide while under my care.

If this is more than luck, it is because I fear my enemy. I know depression is every bit as painful as cancer (which studies have proven) and every bit as stealthy. I don’t dance with it or coddle it; I let myself despise it and wage war against it — like the malignancy it is.

When depression won’t yield to psychotherapy, which is designed to uncover the unresolved traumas or hidden truths that can fuel it, I deploy medicines — including, when necessary, Ketamine infusions and even, in rare cases, opiates like oxycodone. I have used methadone to blunt it, too. When psychotherapy and medications don’t work, I add new technologies, including repetitive transcranial magnetic stimulation (rTMS and deep rTMS) and, rarely, ECT (electroconvulsive therapy).

I utterly refuse to give up and will deploy any and every tool at my disposal to win, because I know that every single case of major depression is a puzzle that can potentially be solved. Every one of them. No exception. Period.

Today — at this very instant — many thousands of people around the world are suffering with major depression and convinced that their best path is to end their excruciatingly painful lives. That is never, ever true. It is a fixed and false belief created by the illness itself, like an emotional virus that fools the psychological immune system into surrendering.

Depression is the grand imposter — posing as all powerful. It can be defeated, every time, if you or the person you care about confronts it like the grand imposter that it is. Tell yourself that, if depression is visiting you. Tell any friend with depression. Tell your family members who suffer with it. It is absolutely true. I promise you.

Dr. Keith Ablow is a well known psychiatrist and author. He can be reached at

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