Tina Babock and Taylor Wright combined for 28 points to lead the visiting Panthers.
Babock netted 15 points, while Wright added 13 points. Ayer-Shirley improved to 10-5, 9-3 in Mid-Wach D.
Junior guard Lindsay Werner collected 10 points, but the Crusaders were routed on the road.
Werner added three rebounds for Groton-Dunstable (8-9). Junior guard Melyssa Langell contributed nine points and two rebounds.